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P. R. Kumar, Y. Yu, R. Sternglanz, S. A. Johnston and L. Joshua-Tor, NADP regulates the yeast GAL induction system, Science, 319, 1090-1092 (2008). 3BTS, 3BTV, 3BTU. view pdf.
E. J. Enemark and L. Joshua-Tor, On helicases and other motor proteins,
Curr. Opin. Struc. Biol., 18, 243-257 (2008). doi: 10.1016/j.sbi.2008.01.007.
Invited review article.
Christopher R. Faehnle and Leemor Joshua-Tor, Argonaute confronts new small RNAs, Curr. Opin. Chem. Biol., 11, 569-577 (2007). doi:10.1016/jicbpa.2007.08.032. Invited review article.
N.H. Tolia and L. Joshua-Tor, Slicer and the Argonautes, Nature Chem. Biol., 3(1), 36-43 (2007). DOI: 10.1038/nchembio848.
E. Yigit, P. J. Batista, Y. Bei, K. M. Pang, C. G. Chen, N. H. Tolia, L. Joshua-Tor, S. Mitani, M. J. Simard and C. C. Mello, Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi, Cell, 127(4), 747-57 (2006). DOI:10.1016/j.cell.2006.09.033
P. A. O’Farrell and L. Joshua-Tor, Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease Bleomycin Hydrolase: new insights into active-site structure, Biochem. J., 401, 421-428 (2007). DOI:10.1042/BJ20060641; published online September 28, 2006.
E.
J. Enemark and L. Joshua-Tor, Mechanism of DNA translocation
in a replicative hexameric helicase, Nature, 442,
270-275 (2006). DOI:10.1038/nature04943.2GXA
D.
V. Irvine*, M. Zaratiegui*, N. H. Tolia*, D. B. Goto, D. H. Chitwood,
M. W. Vaughn, L. Joshua-Tor and R. A. Martienssen, Argonaute
slicing is required for heterochromatic silencing and spreading,
Science, 313, 1134-1137 (2006). DOI:10.1126/science.1128813.
Leemor Joshua-Tor, The Argonautes, Cold Spring Harb Symp Quant Biol., 71, 67-72 (2006). Invited review article.
J.
J. Song and L. Joshua-Tor, Argonaute and RNA – getting
into the groove, Curr. Opin. Struc. Biol., 16, 5-11 (2006). DOI:10.1016/j.sbi.2006.01.010.view
pdf.
N.
H. Tolia and L. Joshua-Tor, Strategies for protein coexpression
in Escherichia coli, Nature Methods, 3(1), 55-64 (2006). DOI:10.1038/nmeth0106-55.view
pdf.
N.
H. Tolia, E. J. Enemark, B. K. L. Sim and L. Joshua-Tor, Structural
basis for the EBA-175 erythrocyte invasion pathway of the malaria
parasite Plasmodium falciparum, Cell, 122, 183-193 (2005) (10.1016/j.cell.2005.05.033).
1ZRL, 1ZRO, view
pdf. supplementary
information
F. V. Rivas, N. H. Tolia, J. J. Song, J. P. Aragon,
J. Liu, G. J. Hannon and L. Joshua-Tor, Purified Argonaute2 and
an siRNA form recombinant human RISC,
Nature Struc. Mol. Biol., 12(4), 340-349 (2005). published
online 30 march, 2005 (10.1038/nsmb918).
1Z25, 1Z26, view
pdf. supplementary information
 |
J.
J. Song, S. K. Smith, G. J. Hannon and L. Joshua-Tor, Crystal
structure of Argonaute and its implications for RISC Slicer
activity, Science, 305, 1434-1437 (2004); published
online July 29, 2004 (10.1126/science.1102514). 1U04 ,
view pdf. supplementary
information |
J.
Liu, M. A. Carmell, F. V. Rivas, C. G. Marsden, J. M. Thomson,
J. J. Song, S. M. Hammond, L. Joshua-Tor and G. J. Hannon, Argonaute2
is the catalytic engine of mammalian RNAi, Science, 305,
1437-1441 (2004); published online July 29, 2004 (10.1126/science.1102513). view
pdf. supplementary information
L. Joshua-Tor, siRNAs at RISC, Structure, 12 (7), 1120-1122
(2004). view pdf
Leemor Joshua-Tor and Stephen A. Johnston, The Bleomycin Hydrolases,
in Handbook of Proteolytic Enzymes 2nd edition (A.J. Barrett,
N.D. Rawlings and J. F. Woessner eds.), pp. 1197-1201, Elsevier,
London
(2004). view pdf
A.
S. Auster and L. Joshua-Tor, The DNA-binding domain of HPV-18
E1: crystal
structure, dimerization and DNA binding. J. Biol. Chem., 279
(5), 3733-3742 (2004). E-pub: October 30, 2003. 1R9W ,
view pdf
J. J. Song, J. Liu, N. H. Tolia, J. Schneiderman, S. K. Smith,
R. A. Martienssen, G. J. Hannon and L. Joshua-Tor, The crystal
structure
of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi
effector complexes. Nat. Struct. Biol., 10 (12), 1026-1032
(2003).
1R6Z ,
view pdf. supplementary
information
T. E. Messick, N. H. Chmiel, M. Golinelli, M. R. Langer, L. Joshua-Tor
and S. S. David, Noncysteinyl coordination to the [4Fe-4S]2+ Cluster
of the DNA Repair Adenine Glycosylase MutY introduced via Site-Directed
Mutagenesis. Structural Characterization of an Unusual Histidinyl
Coordinated Cluster. Biochemistry, 41(12), 3931-3942 (2002). 1KQJ ,
view pdf
E. J. Enemark, A. Stenlund and L. Joshua-Tor, Crystal structures
of two intermediates in the assembly of the papillomavirus replication
initiation complex, EMBO J., 21(6), 1487-1496 (2002). 1KSY, 1KSX ,
view pdf
D. M. F. van Aalten, W. Crielaard, K. J. Hellingwerf and L. Joshua-Tor,
Crystal structure of the photoactive yellow protein reconstituted
with caffeic acid at 1.16 Å resolution, Acta Crystallogr.
D., 58(4), 585-590(2002). 1KOU ,
view pdf
D. M. F. van Aalten, A. Haker, J. Hendriks, K. J. Hellingwerf,
L. Joshua-Tor and W. Crielaard, Engineering photocycle dynamics:
crystal
structures and kinetics of threephotoactive yellow protein hinge
bending mutants, J. Biol. Chem., 277(8), 6463-6468 (2002). 1GSV ,1GSW ,1GSX ,
view pdf
S. J. Russell, F. Gonzalez, L. Joshua-Tor and S. A. Johnston, Selective
Chemical Inactivation of AAA Proteins Reveals Distinct Functions
of Proteasomal ATPases, Chem. & Biol. , 8, 941-950
(2001). view pdf
E. J. Enemark, G. Y. Chen, D. E. Vaughn, A. Stenlund and L. Joshua-Tor
, Crystal Structure of the DNA-Binding Domain of the Replication
Initiation Protein E1 from Papillomavirus, Mol. Cell ,
6, 146-158(2000).
1F08 ,
view pdf
D. M. F. van Aalten, C. C. Chong and L. Joshua-Tor , Crystal Structure
of Carboxypeptidase A Complexed with D-Cysteine at 1.75 A - Inhibitor-Induced
Conformational Changes, Biochemistry , 39(33), 10082-10089(2000).
1F57 ,
view pdf
D. M. F. van Aalten, W. Crielaard, K. J. Hellingwerf, and
L. Joshua-Tor , Conformational Substates in Different
Crystal Forms of the Photoactive
Yellow Protein - Correlation with Theoretical and Experimental
Flexibility, Protein Sci ,9, (1), 64-72 (2000). 1D7E ,
view pdf
D. M. F. van Aalten, D. A. Erlanson, G. L. Verdine and L. Joshua-Tor
, A Structural Snapshot of Base Pair Opening in DNA, Proc.
Natl. Acad. Sci., USA ,96 , 11809-11814 (1999). 1CW9 , view
pdf
D. E. Vaughn, J. Rodriguez, Y. Lazebnik and L. Joshua-Tor , Crystal
Structure of the Apaf-1 Caspase Recruitment Domain: An a-Helical
Greek Key Fold for Apoptotic Signaling, J. Mol. Biol ., 293
, 439-447 (1999). 1CY5 , view
pdf
P. A. O'Farrell, F. Gonzalez, W. Zheng, S. A. Johnston and L.
Joshua-Tor , Crystal Structure of Human Bleomycin Hydrolase,
a Self-Compartmentalizing
Cysteine Protease, Structure ,7(6), 619-627 (1999). 1CB5 , 2CB5 , view
pdf
W. Zheng, S. A. Johnston and L. Joshua-Tor , The Unusual Active
Site of Gal6/Bleomycin Hydrolase Can Act as a Carboxypeptidase,
Aminopeptidase,
and Peptide Ligase, Cell ,93 , 103-109 (1998). 1A6R , 3GCB , view
pdf
D. M. F. van Aalten, E. Grotewold and L. Joshua-Tor , Essential
Dynamics from NMR Clusters: Dynamic Properties of the Myb DNA-Binding
Domain
and a Hinge- Bending Enhancing Variant, Methods , 14(3),
318-328 (1998). view pdf
L. Joshua-Tor and S. A. Johnston, The Bleomycin Hydrolases, in
Handbook of Proteolytic Enzymes (A.J. Barrett, N.D. Rawlings
and J. F. Woessner
eds.), pp. 634-638, Academic Press , London (1998).
J. L. Schlessman,
D. Woo, L. Joshua-Tor , J. B. Howard and Douglas C. Rees, Conformational
Variability in Structures of the Nitrogenase
Iron Proteins from Azotobacter vinelandii and Clostridium pasteurianum
, J. Mol. Biol ., 280 , 669-685 (1998). 1CP2 , 2NIP ,
view pdf
L. Joshua-Tor , H.E. Xu, S.A. Johnston and D.C. Rees, Crystal Structure
of a Conserved Protease That Binds DNA: The Bleomycin Hydrolase,
Gal6. Science 269 , 945-950 (1995). 1GCB
L. Joshua-Tor and J.L. Sussman, The coming of Age of DNA Cyrstallography,
Current Opinions in Structural Biology 3, 323-335 (1993).
D.C. Rees, J. Kim, M.M. Geogiadis, H. Komiya, A.J. Chirino, D.
Woo, J. Schlessman. M.K. Chan , L. Joshua-Tor , G. Santillan, P.
Chakrabarti and B.Y. Hsu. Crystal Structures of the Iron Protein
and Molybdenum-Iron Protein of Nitrogenase, in ACS Symposium
on Molybdenum Enzymes ,Cofactors and Model Systems (E.I. Stiefl, D.
Coucouvanis and W.E. Newton, eds.), Series 535, 170-175 (1993).
P.R. Blake, M.W. Day, B.T. Hsu, L. Joshua-Tor , J.-B. Park, D.R.
Hare, M.W.W. Adams, D.C. Rees and M.F. Summers, Comparison of
the X-ray Structure of Native Rubredoxin from P. furiosus with
the
NMR Structure of the Zinc-Substituted Protein, Protein Science ,
1, 1522-1525 (1992). view pdf
M.W. Day, B.T. Hsu, L. Joshua-Tor , J.-B. Park, Z.H. Zhou, M.W.W.
Adams and D.C. Rees, X-ray Crystal Structures of the Oxidized
and Reduced Forms of the Rubredoxin from the Marine Hyperthermolphilic
Archaebacterium Pyrococcus furiosus, Protein Science 1,
1494-1507 (1992). 1CAA , 1CAD ,
view pdf
H.M. Berman, J.L. Sussman, L. Joshua-Tor , C.G. Revich and L.S.
Ripley, A Structural Model for Sequence-Specific Proflavin-DNA
Interactions During In Vitro Frameshift Mutagenesis, J. Biomol.
Struc. Dyn. 10, 317-331 (1992).
L. Joshua-Tor
, F. Frolow, E. Appella, H. Hope, D. Rabinovich and J.L.Sussman,
The Three-Dimensional Structures of Bulge-Containing
DNA Fragments, J. Mol. Biol. 225, 397-431 (1992). 1D31
J.L. Sussman, L. Joshua-Tor , M. Hirshberg, M.A. Saper, F.
Frowlow, H. Hope and E. Appella, A Kinked Model of a DNA Tridecamer
with
an Unpaired Adenosine: Energy Minimization and X-ray Structural
Studies, in Molecular Structure: Chemical Reactivity and
Biological Activity (Stezowski, J.J., ed.), 195-200 (1988).
L. Joshua-Tor , D. Rabinovich, H. Hope, F. Frolow, E. Appella
and J.L. Sussman, The Three-Dimensional Structure of a DNA
Duplex Containing
Looped Out Bases, Nature 334, 82-85 (1988). 1D31. |